[KMU BRAND]関西医科大学 関連施設

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参画部門・成果論文

医化学講座

  • 教授　小林 拓也

成果論文

  1. Nojima S, Fujita Y, Kimura KT, Nomura N, Suno R, Morimoto K, Yamamoto M, Noda T, Iwata S, Shigematsu H, Kobayashi T. Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein. Structure. 2020 Nov 21:S0969-2126(20)30419-6. doi: 10.1016/j.str.2020.11.007. Online ahead of print. PMID: 33264604




薬理学講座

  • 教授　中邨 智之
  • 准教授　赤間 智也

成果論文

  1. Tsutsumiuchi, M., Hoshino,H., Kogami, A., Tsutsumiuchi, T., Yokoyama, O., Akama, T.O., M. Kobayashi, M., Preferential expression of sialyl 6’-sulfo N-acetyllactosamine-capped O-glycans on high endothelial venules in human peripheral lymph nodes. Lab. Invest. 99, 1428-1441 (2019)




微生物学講座

  • 教授　藤澤 順一

成果論文

  1. H. Katsuya, S. Islam, B. J. Y. Tan, J. Ito, P. Miyazato, M. Matsuo, Y. Inada, S. C. Iwase, Y. Uchiyama, H. Hata, T. Sato, N. Yagishita, N. Araya, T. Ueno, K. Nosaka, M. Tokunaga, M. Yamagishi, T. Watanabe, K. Uchimaru, J.-I. Fujisawa, A. Utsunomiya, Y. Yamano, and Y. Satou . The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach. Cell Reports, 2019, 29, 3, 724–735.
  2. J. Yao, M. Tanaka, N. Takenouchi, Y. Ren, S.-I. Lee, J.-I. Fujisawa. Induction of APOBEC3B cytidine deaminase in HTLV-1-infected humanized mice. Induction of APOBEC3B cytidine deaminase in HTLV-1-infected humanized mice. Exp Ther Med, 2019, 17, 5, 3701-3708.




iPS・幹細胞再生医学講座

  • 教授　人見 浩史
  • 研究教授　服部 文幸
  • 准教授　藤岡 龍哉

成果論文

  1. Matsuoka Y, Sumide K, Sonoda Y. One-Year Observation of the SCID-Repopulating Cell Activities of Human Cord Blood-Derived CD34-Positive and -Negative Hematopoietic Stem Cells. Stem Cell Rev Rep. 2019;15:459-461.
  2. Tamaki H, Ikegame K, Yoshihara S, Kaida K, Yoshihara K, Inoue T, Kato R, Nakata J, Fujioka T, Soma T, Okada M, Ogawa H. Low incidence of HHV-6 reactivation in haploidentical hematopoietic stem cell transplantation with corticosteroid as graft-vs-host disease prophylaxis compared with cord blood transplantation. Transpl Infect Dis. 2019;21:e13073.
  3. Yamashita H, Fukuda K, Hattori F. Hepatocyte-like cells derived from human pluripotents stem cells can be enriched by combination of mitochondorial content and activated leukocyte cell adhesion molecule. JMA Journal. 2019;2:174.
  4. S. Nishimoto, T. Mizuno, K Takahashi, F. Nagano, Y. Yuzawa, A. Nishiyama, K. Osafune, H. Hitomi, and T. Nagamatsu, CD140b and CD73 are markers for human induced pluripotent stem cell-derived erythropoietin-producing cells, FEBS openbio, Epub ahead of print, doi: 10.1002/2211/5463.12800, 2020
  5. Failure to confirm an SGLT2 inhibitor-induced hematopoietic effect in non-diabetic rats with renal anemia., J Diabetes Investig, doi: 10.1111/jdi.13205, 2020
  6. Retinoic acid regulates erythropoietin production cooperatively with hypoxia-inducible factors in human iPSC-derived erythropoietin-producing cells, Sci Rep, doi: 10.1038/s41598-021-83431-6, 2021




分子遺伝学部門

  • 教授　木梨 達雄

成果論文

  1. Konishi Y, Terai K, Furuta Y, Kiyonari H, Abe T, Ueda Y, Kinashi T, Hamazaki Y, Takaori-Kondo A, Matsuda M. Live-Cell FRET Imaging Reveals a Role of Extracellular Signal-Regulated Kinase Activity Dynamics in Thymocyte Motility, iScience. 2018 Dec 21;10:98-113.
  2. Bogdanova D, Takeuchi A, Ozawa M, Kanda Y, Rahman MA, Ludewig B, Kinashi T, Katakai T.　 Essential Role of Canonical NF-κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs,　J Immunol. 2018 Dec 15;201(12):3580-3586.
  3. Kanda Y, Takeuchi A, Ozawa M, Kurosawa Y, Kawamura T, Bogdanova D, Iioka H, Kondo E, Kitazawa Y, Ueta H, Matsuno K, Kinashi T, Katakai T. Visualizing the Rapid and Dynamic Elimination of Allogeneic T Cells in Secondary Lymphoid Organs. J Immunol. 2018 ;201(3):1062-1072.
  4. Ueda Y, Kondo N, Kinashi T. MST1/2 Balance Immune Activation and Tolerance by Orchestrating Adhesion, Transcription, and Organelle Dynamics in Lymphocytes. Front Immunol. 2020 May 6;11:733. doi: 10.3389/fimmu.2020.00733.
  5. Kawai K., Tomonou M., Machida Y., Karuo Y., Tarui A. Sato K., Ikeda Y., Kinashi T., Omote M., Effect of Learning Dataset for Identification of Active Molecules: A Case Study of Integrin αIIbβ3 Inhibitors. Mol Inform. 2021 Mar 18. doi: 10.1002/minf.202060040. Online ahead of print.
  6. Suzuki K., Iwai H., Utsunomiya K.,Kono Y., Kobayashi Y., Bui DV., Sawada S., Yun Y., Mitani A., Kondo N., Katano T., Tanigawa N., TAkama T., Kanda A., Combination therapy with lenvatinib and radiation significantly inhibits thyroid cancer growth by uptake of tyrosine kinase inhibitor, Exp Cell Res.. 2021 Jan 1;398(1):112390. doi: 10.1016/j.yexcr.2020.112390. Epub 2020 Nov 21.




生体情報部門

  • 准教授　松田 達志

成果論文

  1. Imanishi, T., Unno, M., Kobayashi, W., Yoneda, N., Matsuda, S., Ikeda, K., Hoshii, T., Hirao, A., Miyake, K., Barber, G.N., Arita, M., Ishii, K.J., Akira, S., and Saito, T. Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function. Life Sci. Alliance. 2019 2(1). pii: e201800282.
  2. Mami Sumiyoshi, Yui Kotani, Yuki Ikuta, Kazutomo Suzue, Madoka Ozawa, Tomoya Katakai, Taketo Yamada, Takaya Abe, Kana Bando, Shigeo Koyasu, Yasunori Kanaho, Toshio Watanabe and Satoshi Matsuda. Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation. J.Immunol. 2021 206: 366-375.




侵襲反応制御部門

  • 学長特命教授　廣田 喜一
  • 講師　松尾 禎之

成果論文

  1. H. Bono, K. Hirota, Meta-analysis of hypoxic transcriptomes from public databases, bioRxiv (2019) 267310. https://doi.org/10.1101/267310.
  2. T. Shoji, M. Hayashi, C. Sumi, M. Kusunoki, T. Uba, Y. Matsuo, H. Kimura, K. Hirota, Pharmacological polysulfide suppresses glucose-stimulated insulin secretion in an ATP-sensitive potassium channel-dependent manner. Sci Rep 9 (2019) 19377. 10.1038/s41598-019-55848-7.
  3. M. Kusunoki, M. Hayashi, T. Shoji, T. Uba, H. Tanaka, C. Sumi, Y. Matsuo, K. Hirota, Propofol inhibits stromatoxin-1-sensitive voltage-dependent K(+) channels in pancreatic beta-cells and enhances insulin secretion, PeerJ 7 (2019) e8157. 10.7717/peerj.8157.
  4. H. Tanaka, Y. Matsuo, N. So, K. Nishi, A. Okamoto, S. Kai, T. Iwai, Y. Tabata, T. Tajima, Y. Komatsu, M. Sato, K. Kryukov, T. Imanishi, K. Hirota, Real-time diagnostic analysis of MinIONTM-based metagenomic sequencing in clinical microbiology evaluation: a case report, JA Clinical Reports 5 (2019) 24.
  5. C. Sumi, Y. Matsuo, M. Kusunoki, T. Shoji, T. Uba, T. Iwai, H. Bono, K. Hirota, Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma, PLoS ONE 14 (2019) e0215072. 10.1371/journal.pone.0215072.
  6. K. Hirota, An intimate crosstalk between iron homeostasis and oxygen metabolism regulated by the hypoxia-inducible factors (HIFs), Free Radic Biol Med 133 (2019) 118-129. 10.1016/j.freeradbiomed.2018.07.018.
  7. S. Kai, Y. Matsuo, S. Nakagawa, K. Kryukov, S. Matsukawa, H. Tanaka, T. Iwai, T. Imanishi, K. Hirota, Rapid bacterial identification by direct PCR amplification of 16S rRNA genes using the MinION nanopore sequencer, FEBS Open Bio 9 (2019) 548-557. 10.1002/2211-5463.12590.
  8. 甲斐 慎一, 松尾 禎之, 広田 喜一 MinIONTMを使ったクリニカルシークエンシングが拓く病原菌同定の新スタンダード：オンサイトでの感染症診断を可能にする超小型シークエンシングシステム, Intensivist 11 (2019) 386-390.
  9. T. Sakai Y. Matsuo, K. Okuda, K. Hirota, M. Tsuji, T. Hirayama, H. Nagasawa. Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment. Sci Rep (2021) 11:4852.
  10. Y. Matsuo, S. Komiya, Y. Yasumizu, Y. Yasuoka, K. Mizushima, T. Takagi, K. Kryukov, A. Fukuda, Y. Morimoto, Y. Naito, H. Okada, H. Bono, S. Nakagawa, K. Hirota. Full-length 16S rRNA gene amplicon analysis of human gut microbiota using MinION nanopore sequencing confers species-level resolution. BMC Microbiol (2021) 21:35.
  11. N. Kida, Y. Matsuo, Y. Hashimoto, K. Nishi, T. Tsuzuki-Nakao, H. Bono, T. Maruyama, K. Hirota, H. Okada. Cigarette Smoke Extract Activates Hypoxia-Inducible Factors in a Reactive Oxygen Species-Dependent Manner in Stroma Cells from Human Endometrium. Antioxidants (Basel) (2021) 10: 48.
  12. S. Boku, M. Watanabe, M. Sukeno, T. Yaoi, K. Hirota, M. Iizuka-Ohashi, K. Itoh, T. Sakai, Deactivation of Glutaminolysis Sensitizes PIK3CA-Mutated Colorectal Cancer Cells to Aspirin-Induced Growth Inhibition, Cancers (Basel) 12 (2020). 10.3390/cancers12051097.
  13. H. Bono, K. Hirota, Meta-Analysis of Hypoxic Transcriptomes from Public Databases, Biomedicines 8 (2020) E10. 10.3390/biomedicines8010010.
  14. K. Hirota, Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and its Implication for Medicine, Biomedicines 8 (2020) E32. 10.3390/biomedicines8020032.
  15. Y. Fujii, K. Hirota, Critical Care Demand and Intensive Care Supply for Patients in Japan with COVID-19 at the Time of the State of Emergency Declaration in April 2020: A Descriptive Analysis, Medicina (Kaunas) 56 (2020). 10.3390/medicina56100530.
  16. S. Komiya, Y. Naito, H. Okada, Y. Matsuo, K. Hirota, T. Takagi, K. Mizushima, R. Inoue, A. Abe, Y. Morimoto, Characterizing the gut microbiota in females with infertility and preliminary results of a water soluble dietary fiber intervention study, J. Clin. Biochem. Nutr. 67 (2020) 105–111. 10.3164/jcbn.20 53.
  17. K. Kojima, A.T. Nishida, K. Tashiro, K. Hirota, T. Nishio, M. Murata, N. Kato, S. Kawaguchi, A. Zine, J. Ito, T.R. Van De Water, Isolation and Characterization of Mammalian Otic Progenitor Cells that Can Differentiate into Both Sensory Epithelial and Neuronal Cell Lineages, Anat Rec (Hoboken) (2020). 10.1002/ar.24335.
  18. M. Kakita-Kobayashi, H. Murata, A. Nishigaki, Y. Hashimoto, S. Komiya, H. Tsubokura, T. Kido, N. Kida, T. Tsuzuki-Nakao, Y. Matsuo, H. Bono, K. Hirota, H. Okada, Thyroid Hormone Facilitates in vitro Decidualization of Human Endometrial Stromal Cells via Thyroid Hormone Receptors, Endocrinology 161 (2020). 10.1210/endocr/bqaa049.
  19. Y. Fujii, Y. Mori, K. Kambara, K. Hirota, M. Yanada, S. Toda, M. Hashiguchi, Pulmonary vein thrombosis and cerebral infarction after video-assisted thoracic surgery of the left upper lobe: a case series, JA Clin Rep 6 (2020) 71. 10.1186/s40981-020-00378-9.
  20. 松川 志乃, 広田 喜一, 周術期炎症マーカー：現状と課題，今後の展望 炎症応答の一歩先へ, Life Support and Anesthesia 27 (2020) 852-857.
  21. 広田 喜一, 藤井 庸祐, ARS-CoV-2 感染と過剰炎症応答・サイトカインストーム 勝敗の帰趨を決めるものは何か？, Life Support and Anesthesia 27 (2020) 858-862.
  22. 広田 喜一, 村田 宮彦, 新宮 興, 1.39 から1.58 へ—動脈血酸素含量の新計算式を提案します, Life Support and Anesthesia 27 (2020) 1125-1127.
  23. 広田 喜一, ミトコンドリアの酸素代謝異常と疾患, 医学のあゆみ 274 (2020) 248-252.
  24. 広田 喜一, 局所麻酔薬／プロポフォールとミトコンドリア障害：HIF-1 活性化による障害軽滅の可能性, Anet 24 (2020) 15-19.




ゲノム解析部門

  • 学長特命教授　日笠 幸一郎

成果論文

  1. Terao C, Ota M, Iwasaki T, Shiokawa M, Kawaguchi S, Kuriyama K, Kawaguchi T, Kodama Y, Yamaguchi I, Uchida K, Higasa K, Yamamoto M, Kubota K, Yazumi S, Hirano K, Masaki Y, Maguchi H, Origuchi T, Matsui S, Nakazawa T, Shiomi H, Kamisawa T, Hasebe O, Iwasaki E, Inui K, Tanaka Y, Ohshima K, Akamizu T, Nakamura S, Nakamura S, Saeki T, Umehara H, Shimosegawa T, Mizuno N, Kawano M, Azumi A, Takahashi H, Mimori T, Kamatani Y, Okazaki K, Chiba T, Kawa S, Matsuda F. IgG4-related disease in the Japanese population: a genome-wide association study. The Lancet Rheumatology 2019, 1 (1), e14-e22.
  2. Nagata M, Setoh K, Takahashi M, Higasa K, Kawaguchi T, Kawasaki H, Wada T, Watanabe A, Sawai H, Tabara Y, Yamada T, Matsuda F, Kosugi S. Association of ALPL variants with serum alkaline phosphatase and bone traits in the general Japanese population: The Nagahama Study. J Hum Genet 2020, 65(3):337-343.
  3. Misawa K, Hasegawa T, Mishima E, Jutabha P, Ouchi M, Kojima K, Kawai Y, Matsuo M, Anzai N, Nagasaki M. Contribution of Rare Variants of the SLC22A12 Gene to the Missing Heritability of Serum Urate Levels. Genetics 2020, 214(4);1079-1090.
  4. Koyama S, Ito K, Terao C, Akiyama M, Horikoshi M, Momozawa Y, Matsunaga H, Ieki H, Ozaki K, Onouchi Y, Takahashi A, Nomura S, Morita H, Akazawa H, Kim C, Seo JS, Higasa K, Iwasaki M, Yamaji T, Sawada N, Tsugane S, Koyama T, Ikezaki H, Takashima N, Tanaka K, Arisawa K, Kuriki K, Naito M, Wakai K, Suna S, Sakata Y, Sato H, Hori M, Sakata Y, Matsuda K, Murakami Y, Aburatani H, Kubo M, Matsuda F, Kamatani Y, Komuro I. Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease. Nat Genet 2020, 52(11):1169-1177.
  5. Okada D, Nakamura N, Setoh K, Kawaguchi T, Higasa K, Tabara Y, Matsuda F, Yamada R. Genome-wide association study of individual differences of human lymphocyte profiles using large-scale cytometry data. J Hum Genet 2020, doi:10.1038/s10038-020-00874-x




内科学第一講座

  • 教授　野村 昌作
  • 准教授　伊藤 量基

成果論文

  1. Tanaka A, Ito T, Kibata K, Inagaki-Katashiba N, Amuro H, Nishizawa T, Son Y, Ozaki Y, Nomura S.　Serum high-mobility group box 1 is correlated with interferon-α and may predict disease activity in patients with systemic lupus erythematosus.　Lupus. 2019 Aug;28(9):1120-1127. doi: 10.1177/0961203319862865. Epub 2019 Jul 12.
  2. Kibata K, Ito T, Inaba M, Tanaka A, Iwata R, Inagaki-Katashiba N, Phan V, Satake　A, Nomura S.　The immunomodulatory-drug, lenalidomide, sustains and enhances interferon-α production by human plasmacytoid dendritic cells.　J Blood Med. 2019 Jul 12;10:217-226. doi: 10.2147/JBM.S206459. eCollection 2019.
  3. Shigesaka, Tomoki Ito,corresponding author Muneo Inaba, Kai Imai, Hideki Yamanaka, Yoshiko Azuma, Akihiro Tanaka, Hideki Amuro, Tohru Nishizawa, Yonsu Son, Atsushi Satake, Yoshio Ozaki, and Shosaku Nomura. Mycophenolic acid, the active form of mycophenolate mofetil, interferes with IRF7 nuclear translocation and type I IFN production by plasmacytoid dendritic cellsMinoru. Arthritis Res Ther. 2020; 22: 264.
  4. Inagaki-Katashiba N, Ito T, Inaba M, Azuma Y, Tanaka A, Phan V, Kibata K, Satake A, Nomura S. Statins can suppress DC-mediated Th2 responses through the repression of OX40-ligand and CCL17 expression. Eur J Immunol. 2019 Nov;49(11):2051-2062. doi: 10.1002/eji.201847992. Epub 2019 Jul 11.
  5. Phan V, Ito T, Inaba M, Azuma Y, Kibata K, Inagaki-Katashiba N, Tanaka A, Satake A, Nomura S. Immunomodulatory drugs suppress Th1-inducing ability of dendritic cells but enhance Th2-mediated allergic responses. Blood Adv. 2020 Aug 11;4(15):3572-3585. doi: 10.1182/bloodadvances.2019001410.




内科学第三講座

  • 教授　岡崎 和一（～2020.3/31）
  • 教授　長沼 誠（2020.4/1～）

成果論文

  1. Ito T, Kawa S, Matsumoto A, Kubota K, Kamisawa T, Okazaki K, Hirano K, Hirooka Y, Uchida K, Masuda A, Ohara H, Shimizu K, Arakura N, Masamune A, Kanno A, Sakagami J, Itoi T, Ito T, Ueki T, Nishino T, Inui K, Mizuno N, Yoshida H, Sugiyama M, Iwasaki E, Irisawa A, Shimosegawa T, Chiba T.　Risk Factors for Pancreatic Stone Formation in Type 1 Autoimmune Pancreatitis: A Long-term Japanese Multicenter Analysis of 624 Patients.　Pancreas. 2019;48:49-54. doi: 10.1097/MPA.0000000000001210.
  2. Kamisawa T, Nakazawa T, Tazuma S, Zen Y, Tanaka A, Ohara H, Muraki T, Inui K, Inoue D, Nishino T, Naitoh I, Itoi T, Notohara K, Kanno A, Kubota K, Hirano K, Isayama H, Shimizu K, Tsuyuguchi T, Shimosegawa T, Kawa S, Chiba T, Okazaki K, Takikawa H, Kimura W, Unno M, Yoshida M.　 Clinical practice guidelines for IgG4-related sclerosing cholangitis.　 J Hepatobiliary Pancreat Sci. 2019 Jan;26(1):9-42. doi: 10.1002/jhbp.596.
  3. Wallace ZS, Zhang Y, Perugino CA, Naden R, Choi HK, Stone JH; ACR/EULAR IgG4-RD Classification Criteria Committee.　 Clinical phenotypes of IgG4-related disease: an analysis of two international cross-sectional cohorts.　 Ann Rheum Dis. 2019 Mar;78(3):406-412. doi: 10.1136/annrheumdis-2018-214603.
  4. Aoi K, Nishio A, Okazaki T, Takeo M, Masuda M, Fukui T, Uchida K, Okazaki K.　 Inhibition of the dephosphorylation of eukaryotic initiation factor 2α ameliorates murine experimental pancreatitis.　 Pancreatology. 2019 Jun;19(4):548-556. doi: 10.1016/j.pan.2019.04.005
  5. Nakamura T, Satoh-Nakamura T, Nakajima A, Kawanami T, Sakai T, Fujita Y, Iwao H, Miki M, Masaki Y, Okazaki T, Ishigaki Y, Kawano M, Yamada K, Matsui S, Saeki T, Kamisawa T, Yamamoto M, Hamano H, Origuchi T, Hirata S, Tanaka Y, Tsuboi H, Sumida T, Okazaki K, Tanaka M, Chiba T, Mimori T, Umehara H.　 Impaired expression of innate immunity-related genes in IgG4-related disease: A possible mechanism in the pathogenesis of IgG4-RD.　 Mod Rheumatol. 2019;11:1-7. doi: 10.1080/14397595.2019.1621475.
  6. Miyoshi H, Kano M, Kobayashi S, Ito T, Masuda M, Mitsuyama T, Nakayama S, Ikeura T, Shimatani M, Uchida K, Takaoka M, Okazaki K.　 A Case of Diffuse Pancreatic Cancer Mimicking Autoimmune Pancreatitis.　 Intern Med. 2019;58(17):2523-2527.: 10.2169/internalmedicine.2689-19.
  7. Okazaki K. Autoimmune Pancreatitis and IgG4-Related Disease: The Storiform Discovery to Treatment. Dig Dis Sci. 2019 Sep;64(9):2385-2394. doi: 10.1007/s10620-019-05746-9.
  8. Wallace ZS, Naden RP, Chari S, Choi H, Della-Torre E, Dicaire JF, Hart PA, Inoue D, Kawano M, Khosroshahi A, Kubota K, Lanzillotta M, Okazaki K, Perugino CA, Sharma A, Saeki T, Sekiguchi H, Schleinitz N, Stone JR, Takahashi N, Umehara H, Webster G, Zen Y, Stone JH; American College of Rheumatology/European League Against Rheumatism IgG4-Related Disease Classification Criteria Working Group. The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease. Arthritis Rheumatol. 2020 Jan;72(1):7-19. doi: 10.1002/art.41120.
  9. Wallace ZS, Naden RP, Chari S, Choi HK, Della-Torre E, Dicaire JF, Hart PA, Inoue D, Kawano M, Khosroshahi A, Lanzillotta M, Okazaki K, Perugino CA, Sharma A, Saeki T, Schleinitz N, Takahashi N, Umehara H, Zen Y, Stone JH; Members of the ACR/EULAR IgG4-RD Classification Criteria Working Group. The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease. Ann Rheum Dis. 2020 Jan;79(1):77-87. doi: 10.1136/annrheumdis-2019-216561.
  10. Kawa S, Kamisawa T, Notohara K, Fujinaga Y, Inoue D, Koyama T, Okazaki K. Japanese Clinical Diagnostic Criteria for Autoimmune Pancreatitis, 2018: Revision of Japanese Clinical Diagnostic Criteria for Autoimmune Pancreatitis, 2011. Pancreas. 2020 Jan;49(1):e13-e14. doi: 10.1097/MPA.0000000000001443.
  11. Masamune A, Kikuta K, Hamada S, Tsuji I, Takeyama Y, Shimosegawa T, Okazaki K; Collaborators.　 Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2016. J Gastroenterol. 2019 Dec 23. doi: 10.1007/s00535-019-01658-7. [Epub ahead of print]
  12. Tsukuda S, Ikeura T, Ito T, Nakamaru K, Masuda M, Hori Y, Ikemune M, Yanagawa M, Tanaka T, Tomiyama T, Yamaguchi T, Ando Y, Uchida K, Fukui T, Nishio A, Terasawa R, Tanigawa N, Okazaki K.　 Clinical implications of elevated serum interleukin-6 in IgG4-related disease.　 PLoS One. 2020 Jan 17;15(1):e0227479. doi: 10.1371/journal.pone.0227479. eCollection 2020.
  13. Masamune A, Kotani H, Sörgel FL, Chen JM, Hamada S, Sakaguchi R, Masson E, Nakano E, Kakuta Y, Niihori T, Funayama R, Shirota M, Hirano T, Kawamoto T, Hosokoshi A, Kume K, Unger L, Ewers M, Laumen H, Bugert P, Mori MX, Tsvilovskyy V, Weißgerber P, Kriebs U, Fecher-Trost C, Freichel M, Diakopoulos KN, Berninger A, Lesina M, Ishii K, Itoi T, Ikeura T, Okazaki K, Kaune T, Rosendahl J, Nagasaki M, Uezono Y, Algül H, Nakayama K, Matsubara Y, Aoki Y, Férec C, Mori Y, Witt H, Shimosegawa T.　 Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-onset Chronic Pancreatitis.　 Gastroenterology. 2020 Jan 10. pii: S0016-5085(20)30017-2. doi: 10.1053/j.gastro.2020.01.005.
  14. Nakamaru K, Tomiyama T, Kobayashi S, Ikemune M, Tsukuda S, Ito T, Tanaka T, Yamaguchi T, Ando Y, Ikeura T, Fukui T, Nishio A, Takaoka M, Uchida K, Leung PSC, Gershwin ME, Okazaki K. Extracellular vesicles microRNA analysis in type 1 autoimmune pancreatitis: Increased expression of microRNA-21.　 Pancreatology. 2020 20(3):318-324.
  15. Takahashi M, Fujinaga Y, Notohara K, Koyama T, Inoue D, Irie H, Gabata T, Kadoya M, Kawa S, Okazaki K; Working Group Members of The Research Program on Intractable Diseases from the Ministry of Labor, Welfare of Japan. Diagnostic imaging guide for autoimmune pancreatitis. Jpn J Radiol. 2020 Jul;38(7):591-612. doi: 10.1007/s11604-020-00971-z.
  16. Satou A, Notohara K, Zen Y, Nakamura S, Yoshino T, Okazaki K, Sato Y. Clinicopathological differential diagnosis of IgG4-related disease: A historical overview and a proposal of the criteria for excluding mimickers of IgG4-related disease. Pathol Int. 2020 Apr 20. doi: 10.1111/pin.12932.
  17. Ito T, Tanaka T, Nakamaru K, Tomiyama T, Yamaguchi T, Ando Y, Ikeura T, Fukui T, Uchida K, Nishio A, Okazaki K. Interleukin-35 promotes the differentiation of regulatory T cells and suppresses Th2 response in IgG4-related type 1 autoimmune pancreatitis. J Gastroenterol. 2020 May 6. doi: 10.1007/s00535-020-01689-5.
  18. Notohara K, Kamisawa T, Kanno A, Naitoh I, Iwasaki E, Shimizu K, Kuraishi Y, Motoya M, Kodama Y, Kasashima S, Nishino T, Kubota K, Sakagami J, Ikeura T, Kawa S, Okazaki K.　 Efficacy and Limitations of the Histological Diagnosis of Type 1 Autoimmune Pancreatitis With Endoscopic Ultrasound-Guided Fine Needle Biopsy With Large Tissue Amounts. Pancreatology. 2020 Jun 18:S1424-3903(20)30205-2. doi: 10.1016/j.pan.2020.05.026.
  19. Tanaka A, Mori M, Kubota K, Naitoh I, Nakazawa T, Takikawa H, Unno M, Kamisawa T, Kawa S, Okazaki K. Epidemiological features of immunoglobulin G4-related sclerosing cholangitis in Japan. J Hepatobiliary Pancreat Sci. 2020 Jun 30. doi: 10.1002/jhbp.793.
  20. Zhang J, Lian M, Li B, Gao L, Tanaka T, You Z, Wei Y, Chen Y, Li Y, Li Y, Huang B, Tang R, Wang Q, Miao Q, Peng Y, Fang J, Lian Z, Okazaki K, Xiao X, Zhang W, Ma X.　 Interleukin-35 Promotes Th9 Cell Differentiation in IgG4-Related Disorders: Experimental Data and Review of the Literature.　 Clin Rev Allergy Immunol. 2020 Jul 25. doi: 10.1007/s12016-020-08803-8.
  21. Notohara K, Kamisawa T, Fukushima N, Furukawa T, Tajiri T, Yamaguchi H, Aishima S, Fukumura Y, Hirabayashi K, Iwasaki E, Kanno A, Kasashima S, Kawashima A, Kojima M, Kubota K, Kuraishi Y, Mitsuhashi T, Naito Y, Naitoh I, Nakase H, Nishino T, Ohike N, Sakagami J, Shimizu K, Shiokawa M, Uehara T, Ikeura T, Kawa S, Okazaki K.　 Guidance for diagnosing autoimmune pancreatitis with biopsy tissues.　 Pathol Int. 2020 Aug 6. doi: 10.1111/pin.12994.
  22. Umehara H, Okazaki K, Kawa S, Takahashi H, Goto H, Matsui S, Ishizaka N, Akamizu T, Sato Y, Kawano M; Research Program for Intractable Disease by the Ministry of Health, Labor and Welfare (MHLW) Japan. The 2020 Revised Comprehensive Diagnostic (RCD) Criteria for IgG4-RD Mod Rheumatol. 2020 Dec 4:1-14. doi: 10.1080/14397595.2020.1859710. Online ahead of print.PMID: 33274670
  23. Manami Ikemune, Kazushige Uchida, Masato Yanagawa, Satoshi Tsukuda, Takashi Tomiyama, Toshihiro Tanaka, Yugo Ando, Tsukasa Ikeura, Takashi Yamaguchi, Toshiro Fukui, Akiyoshi Nishio, Kazuichi Okazaki Possible Involvement of Innate Lymphoid Cells in the Development of Chronic Inflammatory Pancreatic Diseases Journal of the Pancreas (in press)




小児科学講座

  • 教授　金子 一成
  • 准教授　辻 章志

成果論文

  1. Kaneko K, Akagawa S, Akagawa Y, Kimata T, Tsuji S. Our Evolving Understanding of Kawasaki Disease Pathogenesis: Role of the Gut Microbiota. Front Immunol. 2020 Jul 24;11:1616. doi: 10.3389/fimmu.2020.01616. PMID: 32793240; PMCID: PMC7393004.




耳鼻咽喉科・頭頸部外科学講座（歯科・口腔外科含む）

  • 教授　岩井 大
  • 准教授　神田 晃
  • 講師　澤田 俊輔

成果論文

  1. Kanda A, Kondo K, Hosaka N, Kobayashi Y, Bui DV, Yun Y, Suzuki K, Sawada S, Asako M, Nakamura A, Tomoda K, Sakata Y, Tsuta K, Dombrowicz D, Kawauchi H, Fujieda S, Iwai H.Eosinophilic Upper Airway Inflammation in a Murine Model Using an Adoptive Transfer System Induces Hyposmia and Epithelial Layer Injury with Convex Lesions. Med Sci (Basel). 2019 Feb 5;7(2):22. doi: 10.3390/medsci7020022.
  2. Kanda A, Kobayashi Y, Asako M, Tomoda K, Kawauchi H, Iwai H.　Regulation of Interaction between the Upper and Lower Airways in United Airway Disease. Med Sci (Basel). 2019 Feb 11;7(2):27. doi: 10.3390/medsci7020027.
  3. Kobayashi Y, Konno Y, Kanda A, Yamada Y, Yasuba H, Sakata Y, Fukuchi M, Tomoda K, Iwai H, Ueki S. Critical role of CC」L4 in eosinophil recruitment into the airway. Clin Exp Allergy. 2019 Jun;49(6):853-860.
  4. Bui DV, Kanda A, Kobayashi Y, Sakata Y, Kono Y, Kamakura Y, Jinno T, Yun Y, Suzuki K, Sawada S, Asako M, Nakamura A, Dombrowicz D, Utsunomiya K, Noboru T, Tomoda K, Iwai H. A Novel Approach for Investigating Upper Airway Hyperresponsiveness Using Micro-CT in Eosinophilic Upper Airway Inflammation such as Allergic Rhinitis Model. Biomolecules. 2019 Jun 27;9(7). pii: E252.
  5. Kuwahara T, Kobayashi Y, Yun Y, Kanda A, Asako M, Ueki S, Iwai H. Eosinophilic Cholecystitis Occurred in a Patient With Refractory Eosinophilic Airway Inflammation: A Case Report. Allergy Rhinol (Providence). 2019 Aug 19;10:2152656719869607
  6. Kanda A, Yasutaka Y, Van Bui D, Suzuki K, Sawada S, Kobayashi Y, Asako M, Iwai H. Multiple Biological Aspects of Eosinophils in Host Defense, Eosinophil-Associated Diseases, Immunoregulation, and Homeostasis: Is Their Role Beneficial, Detrimental, Regulator, or Bystander? Biol Pharm Bull. 2020;43(1):20-30.
  7. Yun Y, Kanda A, Kobayashi Y, Van Bui D, Suzuki K, Sawada S, Baba K, Yagi M, Asako M, Okazaki H, Ikeda H, Kawamura S, Nakamura A, Dombrowicz D, Tomoda K, Iwai H. Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings. Allergol Int. 2020 Jan 9. pii: S1323-8930(19)30194-7
  8. Kobayashi Y, Kanda A, Yun Y, Dan Van B, Suzuki K, Sawada S, Asako M, Iwai H.Reduced local response to corticosteroids in eosinophilic chronic rhinosinusitis with asthma.Biomolecules. 2020 Feb 18;10(2):E326.
  9. The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions. Kanda A, Yun Y, Bui DV, Nguyen LM, Kobayashi Y, Suzuki K, Mitani A, Sawada S, Hamada S, Asako M, Iwai H.Allergol Int. 2021 Jan;70(1):9-18. doi: 10.1016/j.alit.2020.11.001.
  10. Hamada S, Kobayashi Y, Sakamoto D, Shimamura A, Kuroda K, Kawachi R, Kanda A, Asako M, Gotoh M, Okubo K, Tomoda K, Iwai H. Long-term sublingual immunotherapy provides better effects for patients with Japanese cedar pollinosis. Auris Nasus Larynx. 2021 Jan 29:S0385-8146(21)00021-3.
  11. Suzuki K, Iwai H, Utsunomiya K, Kono Y, Kobayashi Y, Van Bui D, Sawada S, Yun Y, Mitani A, Kondo N, Katano T, Tanigawa N, Akama T, Kanda A. Combination therapy with lenvatinib and radiation significantly inhibits thyroid cancer growth by uptake of tyrosine kinase inhibitor. Exp Cell Res. 2021 Jan 1;398(1):112390.




皮膚科学講座

  • 教授　岡本 祐之（～2020.3/31）
  • 教授　谷崎 英昭（2020.4/1～）
  • 准教授　神戸 直智（～2020.3/31）
  • 准教授　山崎 文和（2020.4/1～）

成果論文

  1. Kishimoto I, Nguyen CTH, Kambe N, Ly NTM, Ueki Y, Ueda-Hayakawa I, Okamoto H. Circulating intermediate monocytes produce TARC in sarcoidosis. Allergol Int. 2019 Oct 26. pii: S1323-8930(19)30162-5. [Epub ahead of print]
  2. Matsuda T, Kambe N, Ueki Y, Kanazawa N, Izawa K, Honda Y, Kawakami A, Takei S, Tonomura K, Inoue M, Kobayashi H, Okafuji I, Sakurai Y, Kato N, Maruyama Y, Inoue Y, Otsubo Y, Makino T, Okada S, Kobayashi I, Yashiro M, Ito S, Fujii H, Kondo Y, Okamoto N, Ito S, Iwata N, Kaneko U, Doi M, Hosokawa J, Ohara O, Saito MK, Nishikomori R;　Clinical characteristics and treatment of 50 cases of Blau syndrome in Japan confirmed by genetic analysis of the NOD2 mutation.　PIDJ members in the JSIAD; PIDJ (Primary Immunodeficiency and Autoinflammatory Diseases Database Project) members in the JSIAD (Japanese Society for Immunodeficiency and Autoinflammatory Diseases).Ann Rheum Dis. 2020 Nov;79(11):1492-1499. doi: 10.1136/annrheumdis-2020-217320. Epub 2020 Jul 9.PMID: 32647028
  3. Takada S, Saito MK, Kambe N.G Ital. Blau Syndrome: NOD2-related systemic autoinflammatory granulomatosis. Dermatol Venereol. 2020 Oct;155(5):537-541. doi: 10.23736/S0392-0488.19.06524-6. Epub 2020 Jul 2.PMID: 32618442




モデル動物部門

  • 講師　村山 正承

成果論文

  1. Arimitsu N, Murayama MA, Suzuki N, et al., Roles of Reelin/Disabled1 pathway on functional recovery of hemiplegic mice after neural cell transplantation; Reelin promotes migration toward motor cortex and maturation to motoneurons of neural grafts. Exp Neurol. 2019; 320: 112970.
  2. Tomochika K, Murayama MA, Suzuki N, et al., Transplantation of Human iPS Cell-derived Neural Cells with an Artificial Nerve Conduit Leads to Cellular Retention in the Transplanted Area and Improves Motor Function in a Mouse Spinal Cord Injury Model. J. St. Marianna Univ. 2019; 10(2): 27-37.
  3. Shimizu J, Murayama MA, Suzuki N. Relationship between skewed T cell differentiation and gut microbiota alternation in human immunological disorders. Precision Medicine. 2019; 2(4): 364-368. Japanese.
  4. Shimizu J, Murayama MA, Suzuki N. Relationship between skewed T cell differentiation and gut microbiota alternation in human immunological disorders. The Allergy in Practice. 2019; 38(7): 599-603. Japanese.
  5. Murayama MA. (Corresponding author). The pathogenic role of the complement activation in the development of osteoarthritis. BIO Clinica. 2019; 34(8): 852-853. Japanese.
  6. Murayama MA. (Corresponding author). Complement system as a therapeutic target for osteoarthritis. Precision Medicine. 2019; 2(11): 1086-1087. Japanese.
  7. Shimizu J, Murayama MA, Suzuki N. Relationship between skewed T cell differentiation and gut microbiota alternation in human immunological disorders. Agricultural Biotechnology. 2019; 3(13). 1260-1264. Japanese.
  8. Murayama MA, Iwakura Y. C1q/TNF-related protein 3 regulates chondrogenic cell proliferation via adiponectin receptor 2 (progestin and adipoQ receptor 2). Translat Regulat Sci. 2020 Apr;2(1):19-23. Corresponding author.
  9. Murayama MA. The relationship between cognitive functions and neuropsychiatric symptoms in Alzheimer’s disease. BIO Clinica. 2020 Apr 10;35(4):377-379. Japanese. Invited. Corresponding author.
  10. Murayama MA. The development of Alzheimer's disease models. BIO Clinica. 2020 Sep 10;35(10):975-977. Japanese. Invited. Corresponding author.
  11. Shimizu J, Murayama MA, Suzuki N. Relationship between skewed T cell differentiation and gut microbiota alternation in human immunological disorders. The Allergy in Practice. 2020 Dec 15;40(14):1210-1214. Secondary Publication. Japanese. Invited.
  12. Yabe R, Chung SH, Murayama MA, Kubo S, Shimizu K, Akahori Y, Maruhashi T, Seno A, Kaifu T, Saijo S, Iwakura Y. TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens. Nat Commun. 2021 Jan 4;12:94.
  13. Murayama MA. The next therapeutic target in osteoarthritis: CTRP3. The Allergy in Practice. 2021 Feb 20; 41(3): 225-228. Japanese. Invited. Corresponding author.




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